tag:blogger.com,1999:blog-7757118243803522394.post699048405048489532..comments2023-04-05T07:37:14.681-07:00Comments on Computational Genomics Lab at IICB: Probability and Likelihood: two similarly different termsSucheta Tripathy PI @ Computational Genomics Group at IICB, Kolkatahttp://www.blogger.com/profile/17433426304045795341noreply@blogger.comBlogger7125tag:blogger.com,1999:blog-7757118243803522394.post-75162899892842545162013-04-30T23:54:38.631-07:002013-04-30T23:54:38.631-07:00@Sucheta Tripathy PI: The sequences used to build...@Sucheta Tripathy PI: The sequences used to build the PWM or PSSM are the experimentally derived Binding sites for a Transcription factor. Anonymoushttps://www.blogger.com/profile/08852418005276737682noreply@blogger.comtag:blogger.com,1999:blog-7757118243803522394.post-64299365726476048802013-04-30T23:35:26.415-07:002013-04-30T23:35:26.415-07:00let me try with another example.
Suppose you are...let me try with another example. <br /><br />Suppose you are tossing a fair coin. Then you can ask the question "what is the probability of getting 5 heads in 10 trials?". In this case we are assuming that the coin is fair and we have no prior data from observation.<br /><br />But, suppose in an observation of 100 trials, you got 80 heads. Then naturally question arises whether the coin is fair or not. But, since it is based on the observation, you can not ask what is the probability of the coin to be a fair coin. The question should be frame like this:-<br /><br />"What is the likelihood that the coin is fair?"<br /><br />Hope it is clear now, a bit, at least??? :)Anonymoushttps://www.blogger.com/profile/08852418005276737682noreply@blogger.comtag:blogger.com,1999:blog-7757118243803522394.post-55053150213322958952013-04-30T18:33:52.094-07:002013-04-30T18:33:52.094-07:00I also have similar queries as Deeksha: How do you...I also have similar queries as Deeksha: How do you derive the probability from the given information? You have scored a PSSM, but it is not clear whether this PSSM is derived from sequences that actually have a binding site or these are the query dataset.Sucheta Tripathy PI @ Computational Genomics Group at IICB, Kolkatahttps://www.blogger.com/profile/17433426304045795341noreply@blogger.comtag:blogger.com,1999:blog-7757118243803522394.post-16523513497932687262013-04-30T07:19:15.563-07:002013-04-30T07:19:15.563-07:00So, i guess this means that likelihood is used whe...So, i guess this means that likelihood is used when there is some experimental data and probablity when there is no full proof data?Deekshahttps://www.blogger.com/profile/15502646199477735223noreply@blogger.comtag:blogger.com,1999:blog-7757118243803522394.post-42519931925388829822013-04-30T03:25:37.332-07:002013-04-30T03:25:37.332-07:00That's great ma'am. Let me remind you, tod...That's great ma'am. Let me remind you, today is 30th April, end of the month. Anonymoushttps://www.blogger.com/profile/08852418005276737682noreply@blogger.comtag:blogger.com,1999:blog-7757118243803522394.post-87966956149595386222013-04-30T03:03:46.829-07:002013-04-30T03:03:46.829-07:00Pen is not for one post... It will be decided in t...Pen is not for one post... It will be decided in the end of the month - the quality writer gets it.Sucheta Tripathy PI @ Computational Genomics Group at IICB, Kolkatahttps://www.blogger.com/profile/17433426304045795341noreply@blogger.comtag:blogger.com,1999:blog-7757118243803522394.post-60708838725988525922013-04-30T02:34:10.544-07:002013-04-30T02:34:10.544-07:00@Dr. Sucheta Tripathy:- Is the pen ready ma'am...@Dr. Sucheta Tripathy:- Is the pen ready ma'am?? :DAnonymoushttps://www.blogger.com/profile/08852418005276737682noreply@blogger.com